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KMID : 0613820140240010061
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Journal of Life Science
2014 Volume.24 No. 1 p.61 ~ p.66
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Effect of Alpina Officinarum Ethanol Extract on Immunoregulatory Activities in the Mice
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Kim Hyang-Suk
Chung Kyung-Tae
Lee In-Hwan
Choi Woo-Bong
Lee Jong-Hwan
Hyun Sook-Kyung
Kim Byung-Woo
Hwang Hye-Jin
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Abstract
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The purpose of this study was to investigate the immunomodulatory effects of Alpina officinarum (AO) ethanol extract on immunocompromised mice. The mice were injected intraperitoneally with an immunosuppressive drug, cyclophosphamide, and then administrated orally with 30, 100, and 300 mg/kg of ethanol extract of AO (AO 30, AO 100, and AO 300, respectively). The concentrations of cytokines and immunoglobulins (IgM, IgA, IgG) in serum were measured. The body weight of the mice and spleen cell number of the AO-fed group showed no significant difference compared to a control group. The concentrations of several cytokines, including IL-2, IFN-r, and TGF-β, in serum showed a significant increase in the AO 100 group compared to the control and other groups (p<0.05). The IL-4 level showed no significant difference in the experimental groups. The supplementation of AO (30, 100, 300 mg/kg) significantly increased the concentration of IgM (p<0.05). The concentration of IgA was significantly increased in the AO 100 group (p<0.05) compared to the control group. It can be concluded that AO ethanol extract enhances immune function by promoting the production of cytokines and immunoglobulins.
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KEYWORD
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Alpinia officinarum, cytokine, immunoglobulin, immunoregulatory effect
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